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Amsterdam: Elsevier Inc

Several clinical studies reported that recurrence of breast cancer was observed more commonly among CYP2D6 IMs or PMs than among NMs[70,113116]

Arginine is also indispensable for IL-2 signaling because arginase deprivation suppresses the expression of the IL-2 receptor [235, 236]

p62 was the only gene to consistently show dose-dependent changes in expression for all drugs tested and at different concentrations (Figure 4a and Supplementary Figure 4)

The advantage of BEMNs over other types of drug delivery vehicles is that they are able to protect the delivered cargo from loss and destruction, maintaining the stability of the therapeutic agent, as well as bypassing the host's immune system surveillance [34, 35]