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In vitro evidence has shown that high-glucose-induced calcium (Ca 2+ ) secretion leads to fragmented mitochondria, resulting in increased ROS production and ERK 1/2 activation (Yu et al., 2011)

AQ1-S Overview It is a synthetic peptide analog of AQ1 (glucagon-like peptide-1) designed for extended activity

The work demonstrated that the A009 extracts inhibited the growth of A549 and H1650 lung cancer cells in a time- and dose-dependent manner, and this was linked with increased apoptosis at 24 and 48 h, with higher induction in H1650 compared to A549 cells

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doi:10.1016/0896-6273(92)90101-I E