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Studies show that immune checkpoint blockade therapy activates CD8+ T cells to secrete IFN-, promoting ACSL4 growth, regulating cellular acyl-chain phospholipid-fatty acid binding to arachidonic acid (AA), and inducing tumor cell ferroptosis (110)

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doi: 10.1016/j.freeradbiomed.2005.10.062 156 de LangeFPKalkmanJSBleijenbergGHagoortPvan der MeerJWMToniI

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