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Cholesterol induces pyroptosis and matrix degradation via msrebp1-driven endoplasmic reticulum stress in intervertebral disc degeneration

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Research has established that Pinealon functions through multiple interconnected pathways: direct genomic regulation via DNA binding, modulation of MAPK/ERK signaling cascades, enhancement of antioxidant enzyme systems, regulation of caspase-3 apoptotic pathways, and stimulation of irisin and serotonin synthesis

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Collagen-based tissues (tendons, ligaments) remodel slowly and can be sensitive to both under-loading (too little stimulus) and over-loading (re-aggravation)

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