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M., & van Loon, L

Nov 2016;215(5):579.e1-579.e5

Overreliance or indiscriminate application may undermine safety and therapeutic value
90 Modification patterns used in clinical studies or for commercial siRNA Early siRNA therapeutic programs typically employ partial or slight modifications by using 2-OMe, 2-F or PS, 91,92 e.g., alternative 2-OMe modifications were placed in the antisense strand of QPI-1007, whereas just one L-DNA was used in the sense strand

A decline in the cellular GSH level is indicative of an ethanol-induced oxidative stress, which is characterized by the generation of toxic acetaldehyde and other reactive molecules in the cell
