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doi: 10.1128/mSystems.00945-21 61 GuiTShimokadoASunYAkasakaTMuragakiY

Non-traditional mechanisms of AR action Processing of AR target genes and transcripts These renewed insights support the ever-increasing complexity and context-dependency that is being recognized in the control of AR over ARE-driven gene expression, which it executes in large part via interactions with its elaborate and diverse protein interactome

Spider angioma, involving central arterioles surrounded by radiating capillaries, occurs in 33% of alcohol-associated cirrhosis cases and is also linked to hepatopulmonary syndrome, arising from increased blood flow to the surface capillaries