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B., Novellino, E., Antolak, H., Azzini, E., Setzer, W
MC4R is expressed in hypothalamus, cortex, hippocampus, and striatum
Moreover, another study of DOX-induced nephrotoxicity in SD rats proved that L-theanine could protect the kidney by reducing the levels of oxidized glutathione (GSSG), gamma-glutamyltransferase 1 (GGT1), NF-B p65, and the percentage of apoptosis indexes in the tissue and plasma, and increasing the levels of GSH and the activities of GPx, glutathione reductase (GR), and glutathione S-transferase (GST) (86)
Each point represents an individual mouse
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