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Treatment There is a lack, to a large extent, of therapeutic measures that lessen the systemic effects of the different contaminants mentioned in this review
Impaired kidney function is also associated with increased IGFBP levels (e.g., IGFBP-1, -2, -3, -4, and -6) (75, 77) and IGFBP-3 protease activity, which subsequently increases low-molecular-weight IGFBP-3 fragments (78), most likely due to a compromised renal IGFBP-clearance ( Figure 4 )
doi: 10.1023/A:1006935908960
Retrieved 29 October 2023
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