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Macrophages, upon activation, secrete more pro-inflammatory cytokines, creating a positive feedback loop that exacerbates the inflammatory response (30)
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Taken together, these studies demonstrate that GPX1 and 2 have important roles in regulating the synthesis and release of proinflammatory mediators
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Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain