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Glutathione has also emerged a key modulator of xenobiotic toxicity, most notably the persistent organic pollutants which are associated with many diseases of impaired metabolic activity, including diabetes, obesity, and cardiovascular disease

2.1.1 Cellular components in TME of HCC Typical cellular components in TME of HCC consist of hepatic stellate cells (HSCs), cancer-associated fibroblasts (CAFs), endothelial cells, NKs, regulatory T cells (Tregs), myeloid-derived suppressor cell (MDSCs) and TAMs (Figure 1) (Tahmasebi Birgani and Carloni, 2017)

This interaction facilitates the dephosphorylation of the intermembrane space protein AIFM1 by PGAM5, which in turn triggers the release and nuclear translocation of AIFM1, ultimately leading to large-scale DNA fragmentation [106]

Bethesda, MD: American Society of Health-System Pharmacists, 2012 p.3619-3622 9

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Cammalleri M., Dal Monte M., Locri F., Pecci V., De Rosa M., Pavone V., Bagnoli P
