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Description
On re-exposure, the drug-protein conjugate cross-links its IgE which bound to the high-affinity receptor and induces the degranulation of mast cells and basophils, and release of inflammatory mediators that induce urticaria, vasodilatation, increased vascular permeability, edema and bronchoconstriction, leading to cardiovascular failure, bronchospasm and even death 2,10
J., Cuthill, I
MMP, matrix metalloproteinases
ISD 35 V and CE 50 V
We found that reaction with all three NO donors quickly depleted the peptide, generating a series of thiol modification products (Fig
