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(2017), who observed increased gut permeability (assessed by the FITC-Dextran assay) in 20 week old, but not 4 week old, spontaneously hypertensive rats (SHR) relative to age-matched Wistar Kyoto (WKY) rats [92]

This means that the subjective stimulant drug effect lasts only up to 8 h, but plasma concentrations of amphetamine remain high