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lipoatrophic diabetes, Wolfram syndrome, Down syndrome, Klinefelter syndrome (XXY males), Turner syndrome, type 1 myotonic dystrophy, muscular dystrophy, Huntington disease, Friedreich ataxia, Prader-Willi syndrome, Werner syndrome, Cockayne syndrome, and others such as those indicated above

Moreover, the competitive consumption of glutamine by tumor cells, along with the release of its metabolites, profoundly influences immune cells and stromal cells within the TME

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Furthermore, mechanistic insights suggest that KD may modulate tumor metabolism and immune responses, thereby contributing to a more therapeutically responsive tumor microenvironment