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Additional changes at the high dose included slight increases in corpora lutea and pre-implantation loss, decline in mating, fertility, and fecundity indices in females and lower mating and fertility indices in males

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Retatrutide activates GLP-1, GIP, and glucagon receptors, making it a triple agonist and the most receptor-diverse obesity compound currently in clinical development

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Therefore, although GSH-deficient T lymphocytes will be activated normally at first, they cannot reprogram their metabolism to meet their increasing energy requirements, resulting in T lymphocytes ferroptosis and causing immune dysfunction (62)