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Delivery method also plays a role
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Three types are of special interest: the van der Waals model, the solvent accessible model and the molecular surface model
204 Similarly, administration of the PRMT5 inhibitor PJ-68 in a CML mouse model with high expression of PRMT5 LSCs could deplete DVL3, thereby inhibiting Wnt/-catenin signaling and significantly prolonging the survival time of a retroviral BCR-ABL-driven CML mouse model
