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Several animal models have also been used to explore ghrelins impact on migratory motor complexes (MMCs), which indicates its ability to stimulate phase II of the MMC through the vagus nerve (18, 19)

Abbreviations MetS: Metabolic syndrome IGF-1: Insulin-like growth factor CVD: Cardiovascular disease T2D: Type 2 diabetes RAS: Protooncogene protein P21 NAFLD: Non-alcoholic fatty liver disease OSA: Obstructive sleep apnea HDL: High density lipoprotein TG: Triglyceride PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase AKT: Protein kinase B GLUT: Glucose transporter FA: Fatty acid FFA: Free fatty ACID IGF-1R: IGF-1 receptor IGFBP: Insulin-like growth factor binding protein IRS: Insulin receptor substrate KO: Knock out LDL: Low density lipoprotein VLDL: Very low density lipoprotein GH: Growth hormone HOMA: Homeostasis model assessment ROS: Reactive oxygen species References Executive Summary of The Third Report of The

5) (Alary et al., 2003)

[DOI] [PubMed] [Google Scholar] Grasemann H, Gaston B, Fang K, Paul K, Ratjen F

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