glutathione for mitochondrial dysfunction Age-related loss of exacerbates menadione-induced inhibition of Complex I Controlling glutathione entry into mitochondria:

Another FIN with a distinct mechanism of action in inducing ferroptosis, RSL3 11 , had similar differential ferroptosis induction in wild-type and IRE1-null MDA-MB-231 cells, suggesting that the effect of IRE1 on ferroptosis sensitivity is not limited to erastin or cystine starvation-induced ferroptosis (Supplementary Fig

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