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As microorganisms colonize the surface of the GAC, they break down complex organic molecules into simpler forms, reducing the total organic carbon (TOC) content of the water

Similarly, Mills et al

Copper is an essential trace element involved in normal biological processes, and peptides are used in cosmetic systems as delivery and signaling components

They may also be necessary when certain medications interfere with B12 absorption or in any other diagnosed condition specifically impacting B12 uptake
