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The mechanism may be that CB-839 and AC220 synergistically deplete glutathione, induce the production of mitochondrial ROS, and lead to apoptosis

Lastly, primary human skin mast cells (hsMC) and human intestinal mast cells (hiMC) are mechanically and enzymatically isolated from human skin or intestinal mucosa and purified by magnetic cell separation of c-Kit+ (CD117) cells

Netz DJA, Stith CM, Stmpfig M, Kpf G, Vogel D, Genau HM, et al

Biochemistry and microbiology of bee-collected almond ( prunus dulcis ) pollen and bee bread