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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Qi J., Kim J.-W., Zhou Z., Lim C.-W., Kim B

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From a functional point of view MOR phosphorylation following sciatic nerve ligature was correlated with desensitization of receptor ability to stimulate the G protein, development of cyclase superactivation, appearance of thermal hyperalgesia and reduced analgesic response to exogenous opioids [10, 76]

Nevertheless, I would suggest avoiding preparations with piperine if taken long-term because theres some concern that the interaction of piperine and curcumin may lead to some potentially negative effects if its taken long-term

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