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3 In B12 deficiency, methylmalonic acid (MMA) can accumulate, and it is thought that elevated MMA, alongside elevated homocysteine, contributes to damage of the myelin sheath (which protects nerve cells and speeds up nerve transmission), which can cause irreversible neurological problems

At a Glance This table summarizes the documented GLOW research protocol for a standard 70 mg vial reconstituted with 3 mL of bacteriostatic water

Doctors must think about these factors when making treatment plans

Patients frequently report an energy change in the first day or two, which is most plausibly B12 in deficient patients, and expectation in everyone else

Molecular medicine (Cambridge, Mass.), 20(1), 658666