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Intracellularly, macrophages internalize iron through various receptors such as the transferrin receptor (TfR) and the hemoglobin-haptoglobin (CD163), and they also have transporters such as ferroportin (FPN) that export iron to the plasma

Medical oversight and appropriate dosing are essential

During exercise, oxygen consumption can increase as much as 100-fold [8] and is associated with rapid increases in ROS production and accumulation

Also, additional environmental factors such as pollutants may also affect its level

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