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Environmental factors in epithelial barrier dysfunction

1 Introduction Atopic dermatitis (AD) is a chronic, recurrent, inflammatory, pruritic dermatosis with complex pathophysiology, involving disruption of the epidermal barrier, microbial dysbiosis within affected lesions, and Th2 immune responses to skin allergens ( Obesity, a major health problem, is a result of metabolic syndrome in adipose tissue and is linked to various chronic immune disorders ( Currently, the association of obesity/overweight with AD is not conclusive