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Description
Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

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CMAJ 2012;184:1593-8
Using advanced electrophysiological techniques, optogenetic activation, and chemogenetic silencing approaches, studies reveal tesofensine inhibits a specific subset of LH GABAergic neurons, reducing their ability to stimulate food-seeking behavior and consumption
