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Clinical efficacy may be greater in SLE than in RA [115]
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PI3K/Akt and MAPK pathways have been shown to mediate downstream signaling of IGF-1 in these cells, although the relative importance of these pathways seems to differ depending on the model systems analyzed
The observed elevation in CNTF expression likely contributes to neuronal differentiation promotion, survival maintenance, and axonal regeneration facilitation, collectively creating a conducive microenvironment for peripheral nerve regeneration.To the best of our knowledge, this represents the first report elucidating the molecular mechanism of DP action through comprehensive protein profiling
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