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Cochrane Database of Systematic Reviews 2004, Issue 3

Relative cell viability (%) was calculated as [(absorbance of the treated group)/(absorbance of the control group)] 100%

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Free radicals are byproducts of normal bodily processes and external factors like pollution, stress, and unhealthy lifestyles

LL6, the most promising novel small molecule kinase inhibitor obtained, induced apoptosis and suppressed the colony-forming capacities of various drug-resistant NSCLC cell lines, suppressed NSCLC cell migration, suppressed NSCLC xenograft tumor growth and Lewis lung carcinoma allograft tumor metastasis in mice, and markedly reduced the number and burden of lung tumors in KrasG12D/+ transgenic mice, with low toxicity (54)