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Also, overexpression of cytosolic APX in chloroplasts led to the rise of plants tolerance to drought and high salinity (Badawi et al., 2004), whereas knock-out mutants have compromised chloroplast scavenging system and increased H 2 O 2 accumulation in leaves (Davletova et al., 2005)

However, long-term use of rapamycin may also lead to side effects such as immunosuppression and interference with protein synthesis [288]

The New England Journal of Medicine, 360 (8), 765773