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Nature 423 (6937), 293298
Methylmalonic acid (MMA) and homocysteine : These biomarkers rise when B12 levels are low, often before serum B12 drops, helping to detect deficiencies
114,115,116 Additionally, NADH or FADH 2 is the electron carrier for the mitochondrial membrane proteins, such as GPDM and FQR, and the metabolic enzymes in matrix, such as OGDH and PDH, all of which contribute to ROS production
Graphical abstract Similar content being viewed by others The importance of autophagy in cell homeostasis Autophagy and the ubiquitin proteasome system (UPS) are two major intracellular degradative mechanisms that mediate the catabolism of proteins and organelles
10.1002/iub.1017 118 SuzukiK.MiyaK
