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The first hepcidin was identified as an antimicrobial agent in human blood filtrate and denoted LEAP-1 (liver expressed antimicrobial peptide) [154]

MOTS-c (New England Peptide, USA) was administered daily at 5 or 15 mg/kg via intraperitoneal injections

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An additional argument is a direct demonstration of the healing of the severely injured muscles (15-17) and severely injured nerves (18) and brain injuries (19-23) not relied on immunomodulation