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14 After escaping from endosomes, the next challenge is transporting NADs quickly and effectively to the nucleus or specific organelles

Promising modifications include the addition of lipophilic groups to improve membrane permeability and targeted delivery systems using nanocarriers

2.3 Polyphenols 2.3.1 Curcuma longa curcumin Curcumin (CUR) reversibly inhibits MAO-B to reduce HO production (44) and activates the Nrf2/ARE signaling pathway, upregulating HO-1 and NQO1 and scavenging ROS (45)

Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, et al

Apoptosis detection (Biolegend) was conducted using a BD FACS Canto II flow cytometer