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Moreover, the mitochondria also control intracellular Ca 2+ homeostasis, which are essential for the regulation of neurotransmitter exocytosis, and in the regulation of gene expression
281 By reducing macrophage-mediated inflammatory responses, GLP-1RAs have the potential to alleviate symptoms of OA, including pain and joint stiffness

All NOS enzymes also require Zn 2+ ions for function

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