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While multiple published studies have drawn relationships between these SNPs and a wide variety of diseases, the American College of Medical Genetics has issued an official Practice Guideline recommending against testing or reporting on these two variants, citing "Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous thromboembolism

It prevents the synthesis of several proinflammatory cytokines, such as TNF, IL6, and IL1, that are involved in the pathogenesis of cardiovascular diseases (Shabana et al

Cold-to-cold mixing can cause incomplete dissolution