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Ethical approval of animal use All experiment procedures were performed in accordance with the relevant guidelines and regulations of the animal welfare committee at the Faculty of Veterinary Medicine, Mansoura University, Egypt, and approved with registration code number: MU-ACUC (VM.R.24.09.178)
That is why nausea and flushing are common early complaints
10.1038/nnano.2016.23 Nat
