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Previous melanocortin agonists that failed clinical trials for general obesity share common features that constrain their therapeutic windows, including low receptor potency, poor safety profiles, and suboptimal pharmacokinetics

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The presence of resistance-associated substitutions (RAS) as natural polymorphisms in the NS5B gene affects HCV susceptibility to sofosbuvir and dasabuvir and may limit the clinical effectiveness of DAA combinations containing these drugs 45,46

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In addition to the TMA precursors mentioned above, TMAO itself is also an important source of TMAO in human

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Pancreatic enzyme replacement therapy in cystic fibrosis: Australian guidelines

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Metabolites of PPC circulate and stay in the liver and intestines for up to 15 days

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