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Due to this relationship, scientists have theorized that IGF-1 can be used to treat diabetes, especially if started prior to puberty

Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

References : National Center for Biotechnology Information

While some peptides are FDA-approved medications that have undergone extensive clinical testing, others are experimental compounds that lack regulatory oversight and safety data

To elucidate the mechanism by which BDNF regulates NUCKS1, we initially validated the involvement of the TrkB receptor