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Nevertheless, in a mediation analysis of the effects of liraglutide 1.8 mg in the LEADER trial [32], the CVD risk reduction was associated mainly with HbA 1c reductions, whereas contributions from other measured parameters (except a weak contribution from improvements in the urine albumin-to-creatinine ratio) were small
Interestingly, the same beta-sheet is reinforced (less solvent-exposed) in CENP-A nucleosomes as an allosteric effect of CENP-C binding (30)
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