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Abstract 4376: OP-1250, a complete estrogen receptor antagonist (CERAN) that shrinks estrogen receptor positive tumors and exhibits favorable pharmacokinetics

doi: 10.1056/NEJMoa2305032 348 SquittiR.GhidoniR.SimonelliI.IvanovaI

There is no validated lab marker for NNMT inhibition outside research labs

In normal cells, hydrogen peroxide is promptly degraded by either glutathione peroxidase (GSHPX) or catalase, but in red cells of G6PD-deficient subjects, GSHPX activity is impaired because GSH is in short supply (Fig 4), and catalase may also be impaired because the intracellular NADPH concentration is low (Gaetani et al , 1994, 1996)

Siegwart, On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles
