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The diagnostic criteria for IC/BPS, based on the proposed guidelines of the European Society for the Study of Interstitial Cystitis, constituted chronic pelvic pain, pressure, or discomfort perceived to be related to the urinary bladder accompanied by at least one other urinary symptom, such as persistent urge to void or urinary frequency, for more than 6 months, and the exclusion of potentially similar diseases 11,25

WSNs are integral to thermoregulation, and their precise manipulation is anticipated to serve as a novel approach to heatstroke treatment
Moreover, the blood-brain barrier (BBB) may break down as a result of the severe systemic inflammatory response brought on by viral infection

Overall, this process is negatively regulated by Wnt/-catenin signaling

10.1038/jid.2013.21 35 FuH.ShangJ.LiM
