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Meanwhile, analysis of the intracellular localization revealed that nuclear-localized MKRN1 was increased in the presence of cisplatin, suggesting that MKRN1 translocates to the nucleus upon DNA damage, and degrades MDM2 in the nucleus (Extended Data Fig

doi: 10.1038/s41392-023-01353-3

We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex interaction of innate immune function, viral replication, hyper-inflammatory state, and HIF-/Sirtuin pathways

GSH is often referred to as the major antioxidant of the cell, though the functions of GSH extend beyond its antioxidant properties to many other essential cellular processes, including detoxification of xenobiotic compounds, modulation of cell proliferation, transport and storage of cysteine and maintenance of redox status [[14], [15], [16], [17]]

Access this chapter Similar content being viewed by others References Janaky R, Cruz-Aguado R, Oja SS, Shaw CA (2007) Glutathione in the nervous system: roles in neural function and health and implications for neurological disease
