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Both flavones identified were competitive inhibitors of DPP-IV as they docked directly into all the three putative active sites of DPP-IV by exhibiting direct interaction, hydrogen bonding, and pipi interaction to substantiate the strong binding affinity and inhibition activity towards DPP-IV by possessing free binding energies of 7.543 and 7.376 kcal/mol, respectively, which further validated the efficacy of PTWE (84)

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The catch is that a compounded drug product qualifies for these exemptions only if the bulk drug substance used to make it meets one of three criteria: (1) it complies with a USP or National Formulary monograph