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368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption

Slower than that may indicate a need for dose adjustment, dietary evaluation, or investigation of other factors

This metabolic shift occurs without stimulating appetite suppression or increasing nervous system activity, making it fundamentally different from traditional weight loss compounds
