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Stimulation of GHS-R1a leads to a dose-dependent increase in circulating GH and IGF-1 levels, promoting anabolic tissue responses. Nagaya , Circulation Research Additionally, GHRP-6 strongly activates ghrelin pathways , which can result in significant appetite stimulation a unique feature that makes it particularly useful during bulking or recovery from injury

Eur J Pharm Biopharm 189:152164

At the site of injury, cannabinoids may decrease the release of tissue activators and sensitizers, modulating nerve cells to control tissue destruction and immune cells to prevent the release of proinflammatory substances

These results suggest that the beneficial effect of hormetic heat shock on survival depends on HSF-1 activity