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Other methods utilize reaction of dialkyl tosyloxymethylphosphonate with an appropriate 9-(2-hydroxyethyl)purine derivative (Figure 4A) or reaction of an analogous purine 2-iodoethyl derivative with diethyl hydroxymethylphosphonate (Figure 4B on the example of adefovir)

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Further studies are required to determine the true effects of therapeutic cooling on the reduction of ammonia levels and the improvement in neurological outcomes in patients with hyperammonaemia

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