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2024 Jul 16];9(5)

Based on its ability to cross the BBB, N-acetylcysteine amide (NACA) has been evaluated for its neuroprotective effect using cell lines and animal models of neurological diseases/disorders

The high dependence of mitochondria on iron for metabolic processes and haem and Fe-S cluster synthesis suggests that iron deficiency profoundly affects mitochondrial processes and extra-mitochondrial pathways that rely on haem, Fe-S cluster cofactors, or mitochondrially derived metabolites produced by iron-dependent processes (e.g., -KG for 2-ODGG enzymes)

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