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In summary, the effects of mechanical stress on MSCs and intervertebral disc-derived stem cells exhibit dependency on loading mode, specific parameters, and microenvironmental context

This suggests that although relapses were largely prevented, these patients had underlying progression, and there is a need for another class of medications to tackle progressive disease

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Participation with an SSP is associated with lower rates of HIV and Hepatitis C and an increased likelihood of engaging in other forms of treatment as well as drug use cessation.(25) SSPs offer many services including access to sterile syringes, collection of used syringes, and safer use training