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If mitochondrial iron overload is a prominent feature of the disease, the activities of FeS proteins, such as mitochondrial aconitase and succinate dehydrogenase, should be measured to evaluate whether FeS cluster biogenesis is impaired
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Mechanistically, sphingosine-1-phosphate facilitates the binding of deoxygenated Hb to the erythrocyte membrane, promotes the translocation of glycolytic enzymes from the membrane to the cytosol, enhances glycolytic throughput and consequently increases intracellular 2,3-DPG, thereby promoting oxygen release (Reference Sun, Zhang and DAlessandro62)

Psychopharmacology 234, 25252543

Vitamin D may alleviate irritable bowel syndrome by modulating serotonin synthesis: a hypothesis based on recent literature
