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Many patients experience reduced appetite and fluid intake when starting GLP-1 therapy, whilst the medicine's gastrointestinal effects including nausea and occasional vomiting can further affect hydration status

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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

It's particularly important for the transportation of fats and cholesterol in the body