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The synthesis and evaluation of CBD derivatives, especially compounds 19 and 21 with a piperazinyl moiety, showed enhanced antiproliferative effects through the mediation of programmed cell death

Wieser V, Adolph TE, Enrich B, Kuliopulos A, Kaser A, Tilg H, et al

THC treatment significantly augments autophagy [74]

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(2) Enzymatic and non-enzymatic degradation of catecholamines: the MAO pathway induces oxidative deamination of NE to produce hydrogen peroxide (H 2 O 2 ) which is further catalyzed to OH