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if stool sits in the colon too long, the trapped toxins can break free and be reabsorbed
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EFSA Journal
Notably, tyrosinase possesses two copper ions, i.e., CuA and CuBcoordinate with six histidine (His) residues in the conserved catalytic pocket 14,15 , and are critically required to exhibit both types of enzymatic activities 6,16
Furthermore, the model was examined concerning its predictive accuracy by plotting the time-dependent receiver operating characteristic (ROC) curve using the survivalROC R package (version 1.0.3.1)
