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Ghrelin is a multifaceted gut hormone which activates its receptor, growth hormone secretagogue receptor (GHS-R)

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These include modulation of monoaminergic neurotransmission, regulation of the hypothalamicpituitaryadrenal (HPA) axis, promotion of neurogenesis and synaptic plasticity, mitigation of neuroinflammation and oxidative stress, and restoration of gut microbiota homeostasis

TPO antibodies are the hallmark of autoimmune thyroid disease, characterized by chronic inflammation in the thyroid gland